Enantioselective Annulations for Dihydroquinolones by in Situ Generation of Azolium Enolates

نویسندگان

  • Anna Lee
  • Ashkaan Younai
  • Christopher K. Price
  • Javier Izquierdo
  • Rama K. Mishra
  • Karl A. Scheidt
چکیده

A convergent, catalytic asymmetric formal [4 + 2] annulation for the synthesis of dihydroquinolones has been developed. Carboxylic acids can be employed as precursors to NHC enolates through an in situ activation strategy. Simultaneous generation of a reactive aza-o-quinone methide under the basic conditions employed for NHC generation leads to a dual activation approach.

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عنوان ژورنال:

دوره 136  شماره 

صفحات  -

تاریخ انتشار 2014